Connection Refused?

[sharm]

I have closed all AVG processes and have never had a firewall running anyway.
The problem is still persisting. I recieve the same error message.

WinSock 2.0 -- OpenSSL 0.9.8b 04 May 2006
[R] Connecting to Amid The Stars -> DNS=hosting4.123-reg.co.uk IP=195.224.48.69 PORT=21
[R] Connection failed (10061: Connection refused)
[R] Delaying for 120 seconds before reconnect attempt #1
[R] Connecting to Amid The Stars -> DNS=hosting4.123-reg.co.uk IP=195.224.48.69 PORT=21 (attempt # 1)
[R] Connection failed (10061: Connection refused)
[R] Delaying for 120 seconds before reconnect attempt #2

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This is the message I recieve for all my sites, not just Amid The Stars, so I know it is not a hosting issue.

Please could someone advise me as to how to rectify this problem.